Article
Impact of genetic variants of apolipoprotein E on lipid profile in patients with Parkinson's disease.
BioMed research international - 1 Jan 2013
Gregório Michele L, Pinhel Marcela A S, Sado Caroline L, Longo Gabriela S, Oliveira Fábio N, Amorim Gisele S, Nakazone Marcelo A, Florim Greiciane M, Mazeti Camila M, Martins Denise P, Tognola Waldir A, Brandão Antonio C, Júnior Sidney Pinheiro, de Godoy Moacir F, Souza Dorotéia R S
Abstract excerpt
The pathogenesis of Parkinson's disease (PD) seems to involve genetic susceptibility to neurodegeneration. APOE gene has been considered a risk factor for PD. This study aimed to evaluate the association of APOE polymorphism with PD and its influence on lipid profile. We studied 232 PD patients (PD) and 169 individuals without the disease. The studied polymorphism was analyzed by PCR/RFLP. The Fisher's exact...
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