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Article

Glutathione-S-Transferase Theta 2 (GSTT2) Modulates the Response to Bacillus Calmette-Guérin Immunotherapy in Bladder Cancer Patients.

International journal of molecular sciences - 16 Aug 2024

Rahmat Juwita N, Tham Sin Mun, Ong Ting Li, Lim Yew Koon, Patwardhan Mugdha Vijay, Nee Mani Lata Raman, Kamaraj Revathi, Chan Yiong Huak, Chong Tsung Wen, Chiong Edmund, Esuvaranathan Kesavan, Mahendran Ratha

Abstract excerpt

Glutathione-S-transferases (GST) enzymes detoxify xenobiotics and are implicated in response to anticancer therapy. This study evaluated the association of GST theta 1 (GSTT1), GSTT2, and GSTT2B with Mycobacterium bovis Bacillus Calmette-Guérin (BCG) response in non-muscle-invasive bladder cancer treatment. In vitro assessments of GSTT2 knockout (KO) effects were performed using cell lines and dendritic cells...

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Identifiers

PMID: 39201633
DOI: 10.3390/ijms25168947
PMCID: PMC11354831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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