Article
The role of functional polymorphisms in immune response genes as biomarkers of bacille Calmette-Guérin (BCG) immunotherapy outcome in bladder cancer: establishment of a predictive profile in a Southern Europe population.
BJU international - 1 Nov 2015
Lima Luís, Oliveira Daniela, Ferreira José A, Tavares Ana, Cruz Ricardo, Medeiros Rui, Santos Lúcio
Abstract excerpt
OBJECTIVE: To evaluate the predictive value of genetic polymorphisms in the context of bacille Calmette-Guérin (BCG) immunotherapy outcome and create a predictive profile that may allow discrimination of the risk of recurrence. PATIENTS AND METHODS: In a dataset of 204 patients treated with BCG, we evaluated 42 genetic polymorphisms in 38 genes involved in the BCG mechanism of action, using Sequenom MassARRAY(®)...
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