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Article

Large-scale copy number alterations are enriched for synthetic viability in BRCA1/BRCA2 tumors.

Genome medicine - 28 Aug 2024

Zhu Yingjie, Pei Xin, Novaj Ardijana, Setton Jeremy, Bronder Daniel, Derakhshan Fatemeh, Selenica Pier, McDermott Niamh, Orman Mehmet, Plum Sarina, Subramanyan Shyamal, Braverman Sara H, McMillan Biko, Sinha Sonali, Ma Jennifer, Gazzo Andrea, Khan Atif, Bakhoum Samuel, Powell Simon N, Reis-Filho Jorge S, Riaz Nadeem

Abstract excerpt

BACKGROUND: Pathogenic BRCA1 or BRCA2 germline mutations contribute to hereditary breast, ovarian, prostate, and pancreatic cancer. Paradoxically, bi-allelic inactivation of BRCA1 or BRCA2 (bBRCA1/2) is embryonically lethal and decreases cellular proliferation. The compensatory mechanisms that facilitate oncogenesis in bBRCA1/2 tumors remain unclear. METHODS: We identified recurrent genetic alterations enriched...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39198848
DOI: 10.1186/s13073-024-01371-y
PMCID: PMC11351199

Genes

BRCA1
BRCA2
RIC8A
ATM
ATMIN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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