Article
Biallelic loss of RB1 in hepatocellular carcinoma as synthetic lethal target for artificial intelligence-guided therapy.
Signal transduction and targeted therapy - 20 Aug 2026
An Jihyun, Kim Wonkyung, Zhang Xiumei, Chikontwe Philip, Ju Jin-Sung, Oh Bora, Oh Ji-Hye, Yang Eun Ju, Namgung Hyun, Lee Dakeun, Pu Yue, Chen Li-Jie, Park Sang Hyun, Shim Joong Sup, Sung Chang Ohk, Shim Ju Hyun
Abstract excerpt
The retinoblastoma (RB1) gene is a critical tumor suppressor that regulates cell cycle progression and genomic stability. Although RB1 alterations have been reported in hepatocellular carcinoma (HCC), the biological and clinical consequences of biallelic RB1 inactivation (RB1-Bi) remain poorly defined. We performed a comprehensive allele-specific genomic analysis of HCC patients from the TCGA-LIHC (n = 355) and...
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