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Genome-wide CRISPR screens reveal cyclin C as synthetic survival target of BRCA2

23 Jun 2021

Abstract excerpt

Poly (ADP-ribose) polymerase inhibitor (PARPi)-based therapies initially reduce tumor burden but eventually lead to acquired resistance in cancer patients with BRCA1 or BRCA2 mutation. To understand the potential PARPi resistance mechanisms, we performed whole-genome CRISPR screens to discover genetic alterations that change the gene essentiality in cells with inducible depletion of BRCA2. We identified that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34197614
DOI: 10.1093/nar/gkab540

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