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Article

Association Between Schizophrenia-Related Polygenic Liability and the Occurrence and Level of Mood-Incongruent Psychotic Symptoms in Bipolar Disorder.

JAMA psychiatry - 1 Jan 2018

Allardyce Judith, Leonenko Ganna, Hamshere Marian, Pardiñas Antonio F, Forty Liz, Knott Sarah, Gordon-Smith Katherine, Porteous David J, Haywood Caroline, Di Florio Arianna, Jones Lisa, McIntosh Andrew M, Owen Michael J, Holmans Peter, Walters James T R, Craddock Nicholas, Jones Ian, O'Donovan Michael C, Escott-Price Valentina

Abstract excerpt

Importance: Bipolar disorder (BD) overlaps schizophrenia in its clinical presentation and genetic liability. Alternative approaches to patient stratification beyond current diagnostic categories are needed to understand the underlying disease processes and mechanisms. Objective: To investigate the association between common-variant liability for schizophrenia, indexed by polygenic risk scores (PRSs), and...

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Identifiers

PMID: 29167880
DOI: 10.1001/jamapsychiatry.2017.3485
PMCID: PMC5833541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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