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Article

The KCNB2 gene and its role in neurodevelopmental disorders: Implications for genetics and therapeutic advances.

Clinica chimica acta; international journal of clinical chemistry - 30 Jan 2025

Mohamed Zakaria Ahmed, Li Jinghua, Wen Jianping, Jia Feiyong, Banerjee Santasree

Abstract excerpt

Neurodevelopmental disorders (NDDs) are increasingly linked to genetic mutations that disrupt key neuronal processes. The KCNB2 gene encodes a crucial component of voltage-gated potassium channels, essential for regulating neuronal excitability and synaptic transmission. Mutations in KCNB2 typically alter potassium channel inactivation, leading to various NDDs, including autism spectrum disorders (ASD),...

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PMID: 39577484
DOI: 10.1016/j.cca.2024.120056

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