Replication of association of CHRNA4 rare variants with sporadic amyotrophic lateral sclerosis: the Italian multicentre study.

doi:10.3109/17482968.2012.704926

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Article

Replication of association of CHRNA4 rare variants with sporadic amyotrophic lateral sclerosis: the Italian multicentre study.

Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases - 1 Oct 2012

Sabatelli Mario, Lattante Serena, Conte Amelia, Marangi Giuseppe, Luigetti Marco, Del Grande Alessandra, Chiò Adriano, Corbo Massimo, Giannini Fabio, Mandrioli Jessica, Mora Gabriele, Calvo Andrea, Restagno Gabriella, Lunetta Christian, Penco Silvana, Battistini Stefania, Zeppilli Paolo, Bizzarro Alessandra, Capoluongo Ettore, Neri Giovanni, Rossini Paolo Maria, Zollino Marcella

Abstract excerpt

Neuronal nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels widely expressed throughout the mammalian brain, including bulbar and spinal motor neurons. They are involved in neuroprotection and in control of release of many neurotransmitters, including glutamate. Previous data raised the hypothesis that rare variants in the region coding the intracellular loop subunits of nAChRs might...

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PMID: 22873564
DOI: 10.3109/17482968.2012.704926

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CHRNA4

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