Article
Body mass index is lower in asymptomatic C9orf72 expansion carriers but not in SOD1 pathogenic variant carriers compared to gene negatives.
Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 Nov 2024
Lee Ikjae, Garret Mark A, Wuu Joanne, Harrington Elizabeth A, Berry James D, Miller Timothy M, Harms Matthew, Benatar Michael, Shneider Neil
Abstract excerpt
Objective: To examine the relationship between body mass index (BMI) and genotype among pre-symptomatic carriers of different pathogenic variants associated with amyotrophic lateral sclerosis. Methods: C9orf72+ carriers, SOD1+ carriers, and pathogenic variant negative controls (Gene-Negatives) were included from 3 largely independent cohorts: ALS Families Project (ALS-Families); Dominantly inherited ALS (DIALS);...
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