Article
Molecular aspects of BRAF and HER2 in prognosis of periampullary carcinoma.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] - 1 Nov 2024
Apurva, Nimisha, Sharma Abhay Kumar, Kumar Arun, Ahmad Ejaj, Santoshi Seneha, Saluja Sundeep Singh
Abstract excerpt
BACKGROUND: Biological behaviour of Periampullary cancers (PACS) differs from pancreatic head cancer, and analysis of molecular alteration is needed. BRAF and HER2 are keys members of the RAS/RAF and EGFR pathway, playing roles in prognostic markers and therapeutic targets. METHODS: A study on 89 PACS patients, undergoing Whipple Pancreaticoduodenectomy, PCR-RFLP, and qPCR methods used for SNP and mRNA expression...
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