Article
A novel hotspot and rare somatic mutation p.A138V, at TP53 is associated with poor survival of pancreatic ductal and periampullary adenocarcinoma patients.
Molecular medicine (Cambridge, Mass.) - 17 Jun 2020
Saha Gourab, Singh Richa, Mandal Argha, Das Subrata, Chattopadhyay Esita, Panja Prasun, Roy Paromita, DeSarkar Navonil, Gulati Sumit, Ghatak Supriyo, Ghosh Shibajyoti, Banerjee Sudeep, Roy Bidyut, Ghosh Saurabh, Chaudhuri Dipankar, Arora Neeraj, Biswas Nidhan K, Sikdar Nilabja
Abstract excerpt
BACKGROUND: Pancreatic Ductal Adenocarcinoma (PDAC) is a cancer of the exocrine pancreas and 5-year survival rates remain constant at 7%. Along with PDAC, Periampullary Adenocarcinoma (PAC) accounts for 0.5-2% of all gastrointestinal malignancies. Genomic observations were well concluded for PDAC and PACs in western countries but no reports are available from India till now. METHODS: Targeted Next Generation...
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