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Article

Germline Pathogenic Variants in Patients With Pancreatic and Periampullary Cancers.

JCO precision oncology - 1 May 2024

Ando Yohei, Dbouk Mohamad, Yoshida Takeichi, Abou Diwan Elizabeth, Saba Helena, Dbouk Ali, Yoshida Kanako, Roberts Nicholas J, Klein Alison P, Burkhart Richard, He Jin, Hruban Ralph H, Goggins Michael

Abstract excerpt

PURPOSE: Inherited cancer susceptibility is often not suspected in the absence of a significant cancer family history. Pathogenic germline variants in pancreatic cancer are well-studied, and routine genetic testing is recommended in the guidelines. However, data on rare periampullary cancers other than pancreatic cancer are insufficient. We compared the prevalence of germline susceptibility variants in patients...

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Source

Identifiers

PMID: 38781545
DOI: 10.1200/PO.24.00101

Genes

ATM
BAP1
BRCA1
BRCA2
BRIP1
CDKN2A
MLH1
MSH2
MSH6
PALB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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