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Article

Tight regulation of FOXO1 is essential for maintenance of B-cell precursor acute lymphoblastic leukemia

5 Apr 2018

Abstract excerpt

The FOXO1 transcription factor plays an essential role in the regulation of proliferation and survival programs at early stages of B-cell differentiation. Here, we show that tightly regulated FOXO1 activity is essential for maintenance of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Genetic and pharmacological inactivation of FOXO1 in BCP-ALL cell lines produced a strong antileukemic effect associated...

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PMID: 29622548
DOI: 10.1182/blood-2017-10-813576

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