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Article

BRG1 Is a Prognostic Marker and Potential Therapeutic Target in Human Breast Cancer

22 Mar 2013

Abstract excerpt

BRG1, a core component of the SWI/SNF chromatin-remodeling complex, has been implicated in cancer development; however, the biological significance of BRG1 in breast cancer remains unknown. We explored the role of BRG1 in human breast cancer pathogenesis. Using tissue microarray and immunohistochemistry, we evaluated BRG1 staining in 437 breast cancer specimens and investigated its role in breast cancer cell...

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PMID: 23533649
DOI: 10.1371/journal.pone.0059772

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