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Article

Grb2 Y160F mutant mimics the wild-type monomeric state dynamics and the monomer-dimer equilibrium.

International journal of biological macromolecules - 1 Nov 2024

Casteluci G, Dias R V R, Martins I B S, Fernandes R A, Tedesco J A, Caruso I P, de Araujo A S, Itri R, Melo F A

Abstract excerpt

The Growth factor receptor-bound protein 2 (Grb2) participates in early signaling complexes and regulates tyrosine kinase-mediated signal transduction through a monomer-dimer equilibrium. Grb2 dimeric state inhibits signal transduction whereas the monomer promotes signaling downstream. Since Grb2 dimer KD is ∼0.8 μM, studies focused on the monomer are still challenging and require mutations or interaction with...

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PMID: 39182877
DOI: 10.1016/j.ijbiomac.2024.134945

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