Article

An extra-circadian function for human CLOCK in the neocortex

2023-03-14

Abstract excerpt

Core circadian-related proteins such as the transcription factor CLOCK are ubiquitously expressed and important for regulating molecular pathways underlying circadian rhythms. Previous work has suggested that CLOCK has evolved human neocortex-specific gene regulation and therefore may have extra-circadian functions. To test this in vivo, we generated a mouse model that recapitulates human cortical expression of CL...

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Literature Corpus work: 1f16ddad-1100-5076-8a84-2d532ec2206a
DOI: 10.1101/2023.03.13.531623

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