Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TRIM58 functions as a tumor suppressor in colorectal cancer by promoting RECQL4 ubiquitination to inhibit the AKT signaling pathway

29 Jul 2023

Abstract excerpt

BACKGROUND: This study aimed to investigate the underlying molecular mechanisms of TRIM58 in the development of colorectal cancer (CRC). CRC is one of the most common cancers of the digestive tract worldwide. The ubiquitin-proteasome system regulates many oncogenic or tumor-suppressive proteins. TRIM58, an E3 ubiquitin ligase and a member of the tripartite motif protein family, is a potential prognostic marker...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to interferon and immune responses
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37516854
DOI: 10.1186/s12957-023-03124-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TRIM58 functions as a tumor suppressor in colorectal cancer by promoting RECQL4 ubiquitination to inhibit the AKT signaling pathwayPMID 37516854Read ↗

TRIM55 inhibits colorectal cancer development via enhancing protein degradation of c‐MycSemantic proximity Read ↗

Multifaceted Roles of TRIM Proteins in Colorectal CarcinomaSemantic proximity Read ↗

TRIM39 deficiency inhibits tumor progression and autophagic flux in colorectal cancer via suppressing the activity of Rab7Semantic proximity Read ↗

TRIM27 functions as an oncogene by activating epithelial-mesenchymal transition and p-AKT in colorectal cancerSemantic proximity Read ↗

An E3 ligase TRIM1 promotes colorectal cancer progression via K63-linked ubiquitination and activation of HIF1αSemantic proximity Read ↗

TRIM59 facilitates the proliferation of colorectal cancer and promotes metastasis via the PI3K/AKT pathwaySemantic proximity Read ↗

Tripartite motif-containing protein 26 promotes colorectal cancer growth by inactivating p53Semantic proximity Read ↗

TRIM23 overexpression is a poor prognostic factor and contributes to carcinogenesis in colorectal cancerSemantic proximity Read ↗

TRIM21: a multifaceted regulator in cancerSemantic proximity Read ↗

Downregulation of TRIM58 expression is associated with a poor patient outcome and enhances colorectal cancer cell invasionSemantic proximity Read ↗

TRIM family contribute to tumorigenesis, cancer development, and drug resistanceSemantic proximity Read ↗

TRIM28 in cancer and cancer therapySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.