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Article

Unveiling FRG1's DNA repair role in breast cancer.

Scientific reports - 21 Aug 2024

Shubhanjali Shubhanjali, Mohapatra Talina, Khan Rehan, Dixit Manjusha

Abstract excerpt

The FRG1(FSHD region gene 1) gene has emerged as a pivotal tumor suppressor in both breast and prostate cancer. HPF1 (Histone PARylation Factor 1), a gene crucial in the base excision repair (BER) mechanism for single-stranded DNA (ssDNA) lesions, showcases a robust correlation with FRG1. This implies that FRG1 might have the capacity to influence BER via HPF1, potentially playing a role in tumorigenesis. Using a...

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Share to Breast Neoplasms
Share to Cell Line, Tumor
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Gene Expression Regulation, Neoplastic

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Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 39169067
DOI: 10.1038/s41598-024-70368-9
PMCID: PMC11339311

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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