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Topological data analysis communities reveal gene-environment-brain subtypes of major depression in UK Biobank and multi-site cohorts

2025-10-30

Abstract excerpt

Major depressive disorder (MDD) exhibits substantial clinical heterogeneity complicating prognosis definition and treatment selection. Characterizing MDD subtypes through distinct clinical manifestations could enhance personalized therapeutic approaches. We developed a topological data analysis (TDA) framework with graph-based community detection to identify homogeneous patient subgroups using multimodal data inte...

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Literature Corpus work
58a765c0-5656-5e4c-bf65-487b81f84329
DOI
10.1101/2025.10.29.25339044
Open publication

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Topological data analysis communities reveal gene-environment-brain subtypes of major depression in UK Biobank and multi-site cohortsDOI 10.1101/2025.10.29.25339044
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