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Article

Targeting cyclin D1 as a therapeutic approach for papillary thyroid carcinoma

22 Jun 2023

Abstract excerpt

Cyclin D1 functions as a mitogenic sensor that specifically binds to CDK4/6, thereby integrating external mitogenic inputs and cell cycle progression. Cyclin D1 interacts with transcription factors and regulates various important cellular processes, including differentiation, proliferation, apoptosis, and DNA repair. Therefore, its dysregulation contributes to carcinogenesis. Cyclin D1 is highly expressed in...

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PMID: 37427143
DOI: 10.3389/fonc.2023.1145082

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