Article
The BRAF V600E mutation in papillary thyroid carcinoma is associated with glucose transporter 1 overexpression.
Thyroid : official journal of the American Thyroid Association - 1 Apr 2012
Grabellus Florian, Worm Karl, Schmid Kurt Werner, Sheu Sien-Yi
Abstract excerpt
BACKGROUND: The glucose transporter 1 (GLUT1) is a key protein that facilitates the extensive glucose uptake of cancer cells, and its overexpression is associated with more aggressive tumor phenotypes. In cases of BRAF mutations, GLUT1 seems to be a target of the constitutive activation of the RAF/MEK/ERK pathway. In this study, we hypothesized that the common BRAF V600E mutation was associated with GLUT1...
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