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Article

HDAC6 inhibition disrupts HDAC6-P300 interaction reshaping the cancer chromatin landscape

18 Aug 2024

Abstract excerpt

BACKGROUND: Histone deacetylases (HDACs) are crucial regulators of gene expression, DNA synthesis, and cellular processes, making them essential targets in cancer research. HDAC6, specifically, influences protein stability and chromatin dynamics. Despite HDAC6's potential therapeutic value, its exact role in gene regulation and chromatin remodeling needs further clarification. This study examines how HDAC6...

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PMID: 39155390
DOI: 10.1186/s13148-024-01725-8

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