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Histone Deacetylase 6 in Health and Disease

1 Feb 2015

Abstract excerpt

Histone deacetylase (HDAC)6 is a member of the class IIb HDAC family. This enzyme is zinc-dependent and mainly localized in the cytoplasm. HDAC6 is a unique isoenzyme with two functional catalytic domains and specific physiological roles. Indeed, HDAC6 deacetylates various substrates including α-tubulin and HSP90α, and is involved in protein trafficking and degradation, cell shape and migration. Consequently,...

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PMID: 25687470
DOI: 10.2217/epi.14.69

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