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Targeting Histone Deacetylases 6 in Dual-Target Therapy of Cancer

3 Nov 2023

Abstract excerpt

Histone deacetylases (HDACs) are the major regulators of the balance of acetylation of histone and non-histone proteins. In contrast to other HDAC isoforms, HDAC6 is mainly involved in maintaining the acetylation balance of many non-histone proteins. Therefore, the overexpression of HDAC6 is associated with tumorigenesis, invasion, migration, survival, apoptosis and growth of various malignancies. As a result,...

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PMID: 38004560
DOI: 10.3390/pharmaceutics15112581

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