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Role of HDAC6 and Its Selective Inhibitors in Gastrointestinal Cancer

2 Dec 2021

Abstract excerpt

Worldwide, cancer is the second leading cause of mortality after cardiovascular diseases. Among the numerous malignant tumors in human, digestive system cancers are the primary cause of morbidity and mortality. Acetylation and deacetylation are crucially involved in cancer occurrence and development; in addition, the deacetylation process is regulated by histone deacetylases (HDACs). Among the 18 human HDACs that...

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Share to Epigenetics and DNA Methylation
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PMID: 34938729
DOI: 10.3389/fcell.2021.719390

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