Article
ADAM19 and HTR4 variants and pulmonary function: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.
Circulation. Cardiovascular genetics - 1 Jun 2014
London Stephanie J, Gao Wei, Gharib Sina A, Hancock Dana B, Wilk Jemma B, House John S, Gibbs Richard A, Muzny Donna M, Lumley Thomas, Franceschini Nora, North Kari E, Psaty Bruce M, Kovar Christie L, Coresh Josef, Zhou Yanhua, Heckbert Susan R, Brody Jennifer A, Morrison Alanna C, Dupuis Josée
Abstract excerpt
BACKGROUND: The pulmonary function measures of forced expiratory volume in 1 second (FEV1) and its ratio to forced vital capacity (FVC) are used in the diagnosis and monitoring of lung diseases and predict cardiovascular mortality in the general population. Genome-wide association studies (GWASs) have identified numerous loci associated with FEV1 and FEV1/FVC, but the causal variants remain uncertain. We...
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