Article
Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome.
Nature medicine - 1 Nov 2022
Chen Lianmin, Zhernakova Daria V, Kurilshikov Alexander, Andreu-Sánchez Sergio, Wang Daoming, Augustijn Hannah E, Vich Vila Arnau, Weersma Rinse K, Medema Marnix H, Netea Mihai G, Kuipers Folkert, Wijmenga Cisca, Zhernakova Alexandra, Fu Jingyuan
Abstract excerpt
The levels of the thousands of metabolites in the human plasma metabolome are strongly influenced by an individual's genetics and the composition of their diet and gut microbiome. Here, by assessing 1,183 plasma metabolites in 1,368 extensively phenotyped individuals from the Lifelines DEEP and Genome of the Netherlands cohorts, we quantified the proportion of inter-individual variation in the plasma metabolome...
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