Article
[Genomic sequence of hepatitis A virus L-A-1 vaccine strain].
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology - 1 Dec 2004
Jiang Chun-lai, Wang Peng-fu, Liu Jing-ye, Zhang Hua-yuan, Wan Zong-ju
Abstract excerpt
OBJECTIVE: To study the genome sequence of hepatitis A virus L-A-1 strain which has been applied for live attenuated vaccine production in China, to compare with other HAV strains, to understand some characteristics of L-A-1 strain, and to find the mechanism of attenuation and cell adaptation. METHODS: Genome fragments were prepared by antigen-capture PCR from infected cell (2BS), PCR products were cloned into T...
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