<i>In vitro</i> and <i>in vivo</i> characterization of a novel hedgehog signaling antagonist in human glioblastoma cell lines

Abstract excerpt

Glioblastoma multiforme (GBM) is composed of heterogeneous and genetically different cells, which are highly invasive and motile. The standard chemotherapeutic agent, temozolomide, affects GBM cell proliferation but is generally unable to prevent tumor recurrence. Hedgehog pathway activation has been reported to be relevant in GBM and different pharmacological pathway modulators have been identified. We report...

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