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Article

The irradiated brain microenvironment supports glioma stemness and survival via astrocyte-derived Transglutaminase 2

2020-02-13

Abstract excerpt

The tumor microenvironment plays an essential role in supporting glioma stemness and radioresistance, and following radiotherapy, recurrent gliomas form in an irradiated microenvironment. Here, we found that astrocytes, when pre-irradiated, increased stemness and survival of co-cultured glioma cells. Tumor-naïve brains increased reactive astrocytes in response to radiation, and mice subjected to radiation prior to...

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Identifiers and source

Literature Corpus work
37df7d11-2f58-58dc-99af-5b6de60c5189
DOI
10.1101/2020.02.12.945329
Open publication

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The irradiated brain microenvironment supports glioma stemness and survival via astrocyte-derived Transglutaminase 2DOI 10.1101/2020.02.12.945329
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