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Integrated genomic/epigenomic analysis stratifies subtypes of clear cell ovarian carcinoma, highlighting their cellular origin.

Scientific reports - 13 Aug 2024

Nishijima Akira, Oda Katsutoshi, Hasegawa Kosei, Koso Takahiro, Asada Kayo, Ikeda Yuji, Taguchi Ayumi, Maeda Daichi, Nagae Genta, Tsuji Shingo, Tatsuno Kenji, Uehara Yuriko, Kurosaki Akira, Sato Sho, Tanikawa Michihiro, Sone Kenbun, Mori Mayuyo, Ikemura Masako, Fujiwara Keiichi, Ushiku Tetsuo, Osuga Yutaka, Aburatani Hiroyuki

Abstract excerpt

The cellular origin of clear cell ovarian carcinoma (CCOC), a major histological subtype of ovarian carcinoma remains elusive. Here, we explored the candidate cellular origin and identify molecular subtypes using integrated genomic/epigenomic analysis. We performed whole exome-sequencing, microarray, and DNA methylation array in 78 CCOC samples according to the original diagnosis. The findings revealed that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39138354
DOI: 10.1038/s41598-024-69796-4
PMCID: PMC11322660

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