Article
Exome Sequencing Landscape Analysis in Ovarian Clear Cell Carcinoma Shed Light on Key Chromosomal Regions and Mutation Gene Networks.
The American journal of pathology - 1 Oct 2017
Murakami Ryusuke, Matsumura Noriomi, Brown J B, Higasa Koichiro, Tsutsumi Takanobu, Kamada Mayumi, Abou-Taleb Hisham, Hosoe Yuko, Kitamura Sachiko, Yamaguchi Ken, Abiko Kaoru, Hamanishi Junzo, Baba Tsukasa, Koshiyama Masafumi, Okuno Yasushi, Yamada Ryo, Matsuda Fumihiko, Konishi Ikuo, Mandai Masaki
Abstract excerpt
Previous studies have reported genome-wide mutation profile analyses in ovarian clear cell carcinomas (OCCCs). This study aims to identify specific novel molecular alterations by combined analyses of somatic mutation and copy number variation. We performed whole exome sequencing of 39 OCCC samples with 16 matching blood tissue samples. Four hundred twenty-six genes had recurrent somatic mutations. Among the 39...
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