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Identification of somatic genetic alterations in ovarian clear cell carcinoma with next generation sequencing.

Genes, chromosomes & cancer - 1 Feb 2018

Shibuya Yusuke, Tokunaga Hideki, Saito Sakae, Shimokawa Kazurou, Katsuoka Fumiki, Bin Li, Kojima Kaname, Nagasaki Masao, Yamamoto Masayuki, Yaegashi Nobuo, Yasuda Jun

Abstract excerpt

Ovarian clear cell carcinoma (OCCC) is the most refractory subtype of ovarian cancer and more prevalent in Japanese than Caucasians (25% and 5% of all ovarian cancer, respectively). The aim of this study is to discover the genomic alterations that may cause OCCC and effective molecular targets for chemotherapy. Paired genomic DNAs of 48 OCCC tissues and corresponding noncancerous tissues were extracted from...

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Adenocarcinoma, Clear Cell
Class I Phosphatidylinositol 3-Kinases
DNA Mismatch Repair
Exome
High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovarian Neoplasms

Protein Phosphatase 2

Proto-Oncogene Proteins p21(ras)

Source

Identifiers

PMID: 29044863
DOI: 10.1002/gcc.22507

Genes

KRAS
BRAF
ERBB2
PDGFRB
PGR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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