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Molecular profiling reveals novel therapeutic targets and clonal evolution in ovarian clear cell carcinoma.

BMC cancer - 14 Nov 2024

Chao Angel, Huang Chen-Yang, Yu Willie, Lin Chiao-Yun, Lin Hao, Chao An-Shine, Lin Cheng-Tao, Chou Hung-Hsueh, Huang Kuang-Gen, Huang Huei-Jean, Chang Ting-Chang, Rozen Steven G, Wu Ren-Chin, Lai Chyong-Huey

Abstract excerpt

BACKGROUND: Ovarian clear cell carcinoma (OCCC) has a disproportionately high incidence among women in East Asia. Patients diagnosed with OCCC tend to experience worse clinical outcomes than those with high-grade serous carcinoma (HGSC) at advanced stages. The unfavorable prognosis of OCCC can be partly attributed to its frequent resistance to conventional chemotherapy. Within a precision medicine framework, we...

Topics

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Adenocarcinoma, Clear Cell
Biomarkers, Tumor
Class I Phosphatidylinositol 3-Kinases
Clonal Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

DNA-Binding Proteins

Exome Sequencing

Molecular Targeted Therapy

Ovarian Neoplasms

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Identifiers

PMID: 39543535
DOI: 10.1186/s12885-024-13125-5
PMCID: PMC11566382

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