Article
Molecular Subclasses of Clear Cell Ovarian Carcinoma and Their Impact on Disease Behavior and Outcomes.
Clinical cancer research : an official journal of the American Association for Cancer Research - 14 Nov 2022
Bolton Kelly L, Chen Denise, Corona de la Fuente Rosario, Fu Zhuxuan, Murali Rajmohan, Köbel Martin, Tazi Yanis, Cunningham Julie M, Chan Irenaeus C C, Wiley Brian J, Moukarzel Lea A, Winham Stacey J, Armasu Sebastian M, Lester Jenny, Elishaev Esther, Laslavic Angela, Kennedy Catherine J, Piskorz Anna, Sekowska Magdalena, Brand Alison H, Chiew Yoke-Eng, Pharoah Paul, Elias Kevin M, Drapkin Ronny, Churchman Michael, Gourley Charlie, DeFazio Anna, Karlan Beth, Brenton James D, Weigelt Britta, Anglesio Michael S, Huntsman David, Gayther Simon, Konner Jason, Modugno Francesmary, Lawrenson Kate, Goode Ellen L, Papaemmanuil Elli
Abstract excerpt
PURPOSE: To identify molecular subclasses of clear cell ovarian carcinoma (CCOC) and assess their impact on clinical presentation and outcomes. EXPERIMENTAL DESIGN: We profiled 421 primary CCOCs that passed quality control using a targeted deep sequencing panel of 163 putative CCOC driver genes and whole transcriptome sequencing of 211 of these tumors. Molecularly defined subgroups were identified and tested for...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.