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Article

Wide-ranging genetic variation in sensitivity to rapamycin in Drosophila melanogaster.

Aging cell - 1 Nov 2024

Harrison Benjamin R, Lee Mitchell B, Zhang Shufan, Young Bill, Han Kenneth, Sukomol Jiranut, Paus Vanessa, Tran Sarina, Kim David, Fitchett Hannah, Pan Yu-Chen, Tesfaye Philmon, Johnson Alia W, Zhao Xiaqing, Djukovic Danijel, Raftery Daniel, Promislow Daniel E L

Abstract excerpt

The progress made in aging research using laboratory organisms is undeniable. Yet, with few exceptions, these studies are conducted in a limited number of isogenic strains. The path from laboratory discoveries to treatment in human populations is complicated by the reality of genetic variation in nature. To model the effect of genetic variation on the action of the drug rapamycin, here we use the growth of...

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PMID: 39135281
DOI: 10.1111/acel.14292
PMCID: PMC11561674

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