Article
A twin analysis to estimate genetic and environmental factors contributing to variation in weighted gene co-expression network module eigengenes.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jan 2025
Gillespie Nathan A, Bell Tyler R, Hearn Gentry C, Hess Jonathan L, Tsuang Ming T, Lyons Michael J, Franz Carol E, Kremen William S, Glatt Stephen J
Abstract excerpt
Multivariate network-based analytic methods such as weighted gene co-expression network analysis are frequently applied to human and animal gene-expression data to estimate the first principal component of a module, or module eigengene (ME). MEs are interpreted as multivariate summaries of correlated gene-expression patterns and network connectivity across genes within a module. As such, they have the potential...
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