Article
Pathway-based factor analysis of gene expression data produces highly heritable phenotypes that associate with age.
G3 (Bethesda, Md.) - 9 Mar 2015
Anand Brown Andrew, Ding Zhihao, Viñuela Ana, Glass Dan, Parts Leopold, Spector Tim, Winn John, Durbin Richard
Abstract excerpt
Statistical factor analysis methods have previously been used to remove noise components from high-dimensional data prior to genetic association mapping and, in a guided fashion, to summarize biologically relevant sources of variation. Here, we show how the derived factors summarizing pathway expression can be used to analyze the relationships between expression, heritability, and aging. We used skin gene...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.