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Article

Plasma microRNA signature in presymptomatic and symptomatic subjects with C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis.

Journal of neurology, neurosurgery, and psychiatry - 1 May 2021

Kmetzsch Virgilio, Anquetil Vincent, Saracino Dario, Rinaldi Daisy, Camuzat Agnès, Gareau Thomas, Jornea Ludmila, Forlani Sylvie, Couratier Philippe, Wallon David, Pasquier Florence, Robil Noémie, de la Grange Pierre, Moszer Ivan, Le Ber Isabelle, Colliot Olivier, Becker Emmanuelle

Abstract excerpt

OBJECTIVE: To identify potential biomarkers of preclinical and clinical progression in chromosome 9 open reading frame 72 gene (C9orf72)-associated disease by assessing the expression levels of plasma microRNAs (miRNAs) in C9orf72 patients and presymptomatic carriers. METHODS: The PREV-DEMALS study is a prospective study including 22 C9orf72 patients, 45 presymptomatic C9orf72 mutation carriers and 43 controls....

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Identifiers

PMID: 33239440
DOI: 10.1136/jnnp-2020-324647
PMCID: PMC8053348

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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