Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic continuum and poor intracytoplasmic sperm injection intracytoplasmic sperm injection prognosis in patients harboring HENMT1 variants.

Andrology - 1 Jul 2025

Wehbe Zeina, Barbotin Anne-Laure, Boursier Angèle, Cazin Caroline, Hograindleur Jean-Pascal, Bidart Marie, Fontaine Emeline, Plouvier Pauline, Puch Florence, Satre Véronique, Arnoult Christophe, Mustapha Selima Fourati Ben, Zouari Raoudha, Thierry-Mieg Nicolas, Ray Pierre F, Kherraf Zine-Eddine, Coutton Charles, Martinez Guillaume

Abstract excerpt

BACKGROUND: Small RNAs interacting with PIWI (piRNAs) play a crucial role in regulating transposable elements and translation during spermatogenesis and are essential in male germ cell development. Disruptions in the piRNA pathway typically lead to severe spermatogenic defects and thus male infertility. The HENMT1 gene is a key player in piRNAs primary biogenesis and dysfunction of HENMT1 protein in meiotic and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to OAT gene
Share to Infertility, Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Prognosis

Share to Sperm Injections, Intracytoplasmic

Share to Spermatozoa

Source

Open in PubMed Open full text

Identifiers

PMID: 39120570
DOI: 10.1111/andr.13730
PMCID: PMC12183014

Genes

HENMT1
OAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic continuum and poor intracytoplasmic sperm injection intracytoplasmic sperm injection prognosis in patients harboring HENMT1 variants.PMID 39120570Read ↗

Functional Investigation of a Novel PIWIL4 Mutation in Nonobstructive Azoospermia During the First Wave of Spermatogenesis.Semantic proximity Read ↗

Genetic and epigenetic insights into non-obstructive azoospermia: mechanisms, biomarkers, and clinical perspectivesSemantic proximity Read ↗

Pathogenic Variants in PET Complex Encoding Genes TDRD12 and EXD1 Impair piRNA Biogenesis and Cause Male Infertility.Semantic proximity Read ↗

A common cause of non-obstructive azoospermia: biallelic MEI1 variants and implications for infertility diagnostics.Semantic proximity Read ↗

Novel biallelic HFM1 variants cause severe oligozoospermia with favorable intracytoplasmic sperm injection outcome.Semantic proximity Read ↗

Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis.Semantic proximity Read ↗

HENMT1: an RNA methyltransferase in biology and disease.Semantic proximity Read ↗

IQCN disruption causes fertilization failure and male infertility due to manchette assembly defectSemantic proximity Read ↗

Loss-of-function variant in TEX44 cause male infertility with asthenoteratozoospermia in humans and miceSemantic proximity Read ↗

Variant PNLDC1, Defective piRNA Processing, and Azoospermia.Semantic proximity Read ↗

Human-specific subcellular compartmentalization of P-element induced wimpy testis-like (PIWIL) granules during germ cell development and spermatogenesisSemantic proximity Read ↗

Inherited defects of piRNA biogenesis cause transposon de-repression, impaired spermatogenesis, and human male infertilitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.