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Article

IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect

2 Nov 2022

Abstract excerpt

Total fertilization failure (TFF) is an important cause of infertility; however, the genetic basis of TFF caused by male factors remains to be clarified. In this study, whole‐exome sequencing was firstly used to screen for genetic causes of TFF after intracytoplasmic sperm injection (ICSI), and homozygous variants in the novel gene IQ motif‐containing N (IQCN) were identified in two affected individuals with...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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Identifiers

PMID: 36321563
DOI: 10.15252/emmm.202216501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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