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Article

IDH1 mutation promotes proliferation and migration of glioma cells via EMT induction.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology - 1 Jan 2000

Lu Jie, Li Depei, Zeng Yu, Wang Hai, Feng Wenfeng, Qi Songtao, Yu Lei

Abstract excerpt

PURPOSE: To investigate whether IDH1 mutation or 2-hydroxyglutarate (2-HG), the oncometabolite produced by IDH mutations, is correlated to epithelial-mesenchymal transition (EMT)-like phenotype in glioma cells, so as to clarify how IDH1 mutation is good prognostic factor while 2-HG, being its oncometabolite, remains unknown. METHODS: U87 and T98 cell lines were treated with 10 mM exogenous 2-HG, and fresh 2-HG...

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PMID: 31983120

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