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Article

Autocrine BMP4 Signaling Enhances Tumor Aggressiveness via Promoting Wnt/β-Catenin Signaling in IDH1-mutant Gliomas

19 Dec 2019

Abstract excerpt

The isocitrate dehydrogenase (IDH1/2) mutations are frequent genetic abnormalities in the majority of WHO grade II/III glioma and secondary GBM. IDH1 -mutated ( IDH1 Mut ) glioma exhibits distinctive patterns in cancer biology and metabolism. In the present study, we showed that bone morphogenetic proteins (BMP4) are significantly upregulated in IDH1 Mut glioma. Further, we demonstrated that cancer-associated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31865175
DOI: 10.1016/j.tranon.2019.10.019

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