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Article

Independent Effects of Blood Pressure on Intraocular Pressure and Retinal Ganglion Cell Degeneration: A Mendelian Randomization Study.

Investigative ophthalmology & visual science - 1 Jul 2024

Rajasundaram Skanda, Segrè Ayellet V, Gill Dipender, Woolf Benjamin, Zekavat Seyedeh M, Burgess Stephen, Khawaja Anthony P, Zebardast Nazlee, Wiggs Janey L

Abstract excerpt

Purpose: To investigate the causal effect of elevated blood pressure on primary open-angle glaucoma (POAG) and POAG endophenotypes. Methods: Two-sample Mendelian randomization (MR) was performed to investigate the causal effect of elevated systolic blood pressure (SBP) (N = 757,601) and diastolic blood pressure (DBP) (N = 757,601) on intraocular pressure (IOP) (N = 139,555), macular retinal nerve fiber layer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 39028976
DOI: 10.1167/iovs.65.8.35
PMCID: PMC11262474

Genes

DBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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