Article
Identifying genetic determinants of sarcopenia-related traits: a Mendelian randomization study of druggable genes.
Metabolism: clinical and experimental - 1 Nov 2024
Wu Jihao, Chen Xiong, Li Ruijun, Lu Qiying, Ba Yucheng, Fang Jiayun, Liu Yilin, Li Ruijie, Liu Yixuan, Wang Yiling, Chen Jinsi, Li Yanbing, Huang Yinong
Abstract excerpt
BACKGROUND: Sarcopenia, characterized by progressive muscle mass and function loss, particularly affects the elderly, and leads to severe consequences such as falls and mortality. Despite its prevalence, targeted pharmacotherapies for sarcopenia are lacking. Utilizing large-sample genome-wide association studies (GWAS) data is crucial for cost-effective drug discovery. METHODS: Herein, we conducted four studies...
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