Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Comprehensive profiling of 1015 patients’ exomes reveals genomic-clinical associations in colorectal cancer

29 Apr 2022

Abstract excerpt

The genetic basis of colorectal cancer (CRC) and its clinical associations remain poorly understood due to limited samples or targeted genes in current studies. Here, we perform ultradeep whole-exome sequencing on 1015 patients with CRC as part of the ChangKang Project. We identify 46 high-confident significantly mutated genes, 8 of which mutate in 14.9% of patients: LYST, DAPK1, CR2, KIF16B, NPIPB15, SYTL2,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Cholangiocarcinoma and Gallbladder Cancer Studies
Share to Genetic factors in colorectal cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35487942
DOI: 10.1038/s41467-022-30062-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Comprehensive profiling of 1015 patients’ exomes reveals genomic-clinical associations in colorectal cancerPMID 35487942Read ↗

A comprehensive multi-omics study reveals potential prognostic and diagnostic biomarkers for colorectal cancerSemantic proximity Read ↗

Genomic Alteration Characterization in Colorectal Cancer Identifies a Prognostic and Metastasis Biomarker: FAM83A|IDO1Semantic proximity Read ↗

Exploring the Role of Non-synonymous and Deleterious Variants Identified in Colorectal Cancer: A Multi-dimensional Computational Scrutiny of ExomesSemantic proximity Read ↗

Prognostic genome and transcriptome signatures in colorectal cancers.Semantic proximity Read ↗

Genomic Alterations Characterization in Colorectal Cancer Identifies a Prognostic and Metastasis Biomarker: FAM83A|IDO1Semantic proximity Read ↗

Whole genome sequencing of 2,023 colorectal cancers reveals mutational landscapes, new driver genes and immune interactionsSemantic proximity Read ↗

Genomic Alterations Characterization in Colorectal Cancer Identifies a Prognostic and Metastasis Biomarker: FAM83A|IDO1Semantic proximity Read ↗

Whole genome sequencing of 2,023 colorectal cancers reveals mutational landscapes, new driver genes and immune interactionsSemantic proximity Read ↗

Integrated multi-omics approach to distinct molecular characterization and classification of early-onset colorectal cancer.Semantic proximity Read ↗

Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival.Semantic proximity Read ↗

Integrated clinicopathological and mutational profiling accumulates histological characteristics of rare and conventional colorectal cancer in Indian patientsSemantic proximity Read ↗

Genome-wide mutation profiles of colorectal tumors and associated liver metastases at the exome and transcriptome levels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.