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Article

Molecular mimicry in multisystem inflammatory syndrome in children

7 Aug 2024

Abstract excerpt

, yet the pathophysiological mechanism connecting the infection to the broad inflammatory syndrome remains unknown. Here we leveraged a large set of samples from patients with MIS-C to identify a distinct set of host proteins targeted by patient autoantibodies including a particular autoreactive epitope within SNX8, a protein involved in regulating an antiviral pathway associated with MIS-C pathogenesis. In...

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Share to Inflammasome and immune disorders
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PMID: 39112696
DOI: 10.1038/s41586-024-07722-4

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