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Article

The autoimmune signature of hyperinflammatory multisystem inflammatory syndrome in children

26 Aug 2021

Abstract excerpt

Multisystem inflammatory syndrome in children (MIS-C) manifests as a severe and uncontrolled inflammatory response with multiorgan involvement, occurring weeks after SARS-CoV-2 infection. Here, we utilized proteomics, RNA sequencing, autoantibody arrays, and B cell receptor (BCR) repertoire analysis to characterize MIS-C immunopathogenesis and identify factors contributing to severe manifestations and intensive...

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PMID: 34437303
DOI: 10.1172/jci151520

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