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Article

SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of Kawasaki disease?

The Journal of experimental medicine - 7 Jun 2021

Sancho-Shimizu Vanessa, Brodin Petter, Cobat Aurélie, Biggs Catherine M, Toubiana Julie, Lucas Carrie L, Henrickson Sarah E, Belot Alexandre, Tangye Stuart G, Milner Joshua D, Levin Michael, Abel Laurent, Bogunovic Dusan, Casanova Jean-Laurent, Zhang Shen-Ying

Abstract excerpt

Multisystem inflammatory syndrome in children (MIS-C) emerged in April 2020 in communities with high COVID-19 rates. This new condition is heterogenous but resembles Kawasaki disease (KD), a well-known but poorly understood and clinically heterogenous pediatric inflammatory condition for which weak associations have been found with a myriad of viral illnesses. Epidemiological data clearly indicate that SARS-CoV-2...

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Identifiers

PMID: 33904890
DOI: 10.1084/jem.20210446
PMCID: PMC8080850

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